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侯保华,男,医学博士,讲师,无党派人士,学科秘书,伟德bv1946官网硕士生导师
联系方式
邮箱:houbaohua@hpu.edu.cn
QQ:940349407
电话:15072330297
主要工作与学习经历:
1.2008年-2012年,河南科技大学,获学士学位
2.2012年-2015年,中南民族大学,获硕士学位
3.2017年-2020年,武汉大学,获医学博士学位
主要研究方向:神经退行性疾病的发病机制及防治。
科研情况:
1.DPP4抑制剂西他列汀的抗癫痫作用及机制研究,2022-2023,河南省科技攻关,主持
2.NLRP3炎性小体调控小胶质细胞表型转化在多发性硬化认知障碍中的作用机制,2022-2023,河南省高等学校重点科研项目,主持
3.DPP4调控TLR4信号在急性呼吸窘迫综合征中的作用,2021-2025,伟德国际1946源自英国博士基金,主持
4.IL-18调控RhoA/ROCK2信号通路诱导星形胶质细胞A1型激活参与多发性硬化认知障碍的机制研究,2024-2026,国家自然科学基金,主持
5.糖尿病中药新药的筛选与开发,2022-2024,横向项目,主持
主要学术论文
(1)*Baohua Hou(第一作者), Jun Yin, Shuyan Liu, Jincheng Guo, Baobao Zhang, Zhenzhen Zhang, Lanping Yang, Xiying Tan, Yijiao Long, Sijie Feng, Jingchun Zhou, Yifan Wu, Xueyang Wang, Song Han, Zhenhui Wang, Xiaohua He. Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice. Molecular neurobiology, 2023
(2)*Baohua Hou(第一作者), Yahui Zhang, Peiyu Liang, Yuan He, Biwen Peng, Wanhong Liu, Song Han, Jun Yin, Xiaohua He. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Cell Death & Disease, 2020, 11(5), 377.
(3)*Yunli Liu, Baohua Hou(共同第一作者), Yusong Zhang, Yuanteng Fan, Biwen Peng, Wanhong Liu, Song Han, Jun Yin, Xiaohua He. Anticonvulsant agent dpp4 inhibitor sitagliptin downregulates CXCR3/RAGE pathway on seizure models. Experimental Neurology, 2018, 307, 90-98.
(4)* Baohua Hou(第一作者), Hengling Chen, Xiangwei Qu, Xianguang Lin, Fang Luo, Chenhong Li. Characteristics of hyperpolarization-activated cyclic nucleotide-gated channels in dorsal root ganglion neurons at different ages and sizes. Neuroreport, 2015, 26(16), 981-987.
(5)Zhicheng Zheng, Peiyu Liang, Baohua Hou, Xin Lu, Qianwen Ma, Xiaomin Yu, Song Han, Biwen Peng, Taoxiang Chen, Wanhong Liu, Jun Yin, Xiaohua He. The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy. J Neuroinflammation. 2021 May 11;18(1):112.
(6)Yangyang Zhai, Zhenhui Wang, Xueyun Gong, Baohua Hou, Xiaorui Cui, Yanfeng Sun, Keyang Wang, Pengwei Liu, Xueyan Li, Dejun Zhou. Applications of hypervalent iodine(iii) reagents in constructing ortho -iodo aromatic ethers. Journal of Chemical Research (2021):174751982110053.